David R Borchelt Selected Research

Superoxide Dismutase-1

1/2021	Variation in the vulnerability of mice expressing human superoxide dismutase 1 to prion-like seeding: a study of the influence of primary amino acid sequence.
1/2020	Tryptophan residue 32 in human Cu-Zn superoxide dismutase modulates prion-like propagation and strain selection.
1/2019	Experimental Mutations in Superoxide Dismutase 1 Provide Insight into Potential Mechanisms Involved in Aberrant Aggregation in Familial Amyotrophic Lateral Sclerosis.
1/2018	Loss of charge mutations in solvent exposed Lys residues of superoxide dismutase 1 do not induce inclusion formation in cultured cell models.
1/2017	Relationship between mutant Cu/Zn superoxide dismutase 1 maturation and inclusion formation in cell models.
12/2014	Experimental transmissibility of mutant SOD1 motor neuron disease.
5/2014	Conformational specificity of the C4F6 SOD1 antibody; low frequency of reactivity in sporadic ALS cases.
1/2014	Analysis of mutant SOD1 electrophoretic mobility by Blue Native gel electrophoresis; evidence for soluble multimeric assemblies.
12/2013	Features of wild-type human SOD1 limit interactions with misfolded aggregates of mouse G86R Sod1.
7/2013	Structural similarity of wild-type and ALS-mutant superoxide dismutase-1 fibrils using limited proteolysis and atomic force microscopy.

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David R Borchelt Research Topics

Disease

48	Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease) 01/2022 - 03/2002
37	Alzheimer Disease (Alzheimer's Disease) 01/2022 - 07/2002
15	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2021 - 04/2008
14	Amyloid Plaque 01/2020 - 04/2003
11	Motor Neuron Disease (Primary Lateral Sclerosis) 01/2021 - 03/2002
11	Huntington Disease (Huntington's Disease) 08/2013 - 03/2002
10	Amyloidosis 01/2022 - 07/2002
9	Parkinson Disease (Parkinson's Disease) 03/2021 - 09/2002
6	Proteostasis Deficiencies 03/2021 - 10/2009
6	Paralysis (Palsy) 11/2020 - 05/2009
4	Tauopathies 01/2022 - 01/2018
4	Neuroinflammatory Diseases 03/2021 - 10/2003
4	Synucleinopathies 03/2021 - 06/2010
4	Frontotemporal Dementia (Semantic Dementia) 12/2018 - 05/2013
3	Disease Progression 01/2022 - 08/2013
3	Distal Myopathies (Distal Muscular Dystrophy) 11/2016 - 01/2015
2	Lewy Body Disease (Lewy Body Dementia) 01/2022 - 01/2021
2	Gliosis 01/2022 - 01/2021
2	Prion Diseases (Transmissible Spongiform Encephalopathies) 01/2021 - 07/2014
2	Muscular Diseases (Myopathy) 01/2019 - 01/2015
2	Atrophy 04/2008 - 07/2002
1	Inflammation (Inflammations) 01/2022
1	Hypertrophy 01/2021
1	Multiple System Atrophy 01/2019
1	Animal Disease Models 01/2019
1	Scrapie 07/2014
1	Dementia (Dementias) 08/2013
1	Cognitive Dysfunction 05/2013
1	Glioma (Gliomas) 01/2012
1	Neuroblastoma 01/2012
1	Spinocerebellar Ataxias (Spinocerebellar Ataxia) 05/2011
1	Parkinsonian Disorders (Parkinsonism) 06/2010
1	Nerve Degeneration 08/2008

Drug/Important Bio-Agent (IBA)

34	Proteins (Proteins, Gene)FDA Link 01/2021 - 08/2002
30	Superoxide Dismutase-1IBA 01/2021 - 03/2002
23	Amyloid (Amyloid Fibrils)IBA 01/2022 - 04/2003
12	Amyloid beta-PeptidesIBA 01/2021 - 07/2002
11	PrionsIBA 01/2022 - 09/2002
11	Peptides (Polypeptides)IBA 01/2020 - 01/2004
7	CopperIBA 06/2015 - 01/2007
7	Superoxide DismutaseIBA 06/2015 - 08/2008
6	ZincIBA 06/2015 - 08/2008
6	Mutant Proteins (Protein, Mutant)IBA 05/2015 - 04/2007
5	SynucleinsIBA 01/2021 - 07/2002
4	Presenilin-1IBA 01/2020 - 08/2004
4	EnzymesIBA 01/2012 - 03/2002
3	Protein AggregatesIBA 01/2022 - 07/2002
3	Apolipoproteins E (ApoE)IBA 01/2022 - 01/2018
3	Apolipoprotein E4IBA 01/2022 - 01/2018
3	ApolipoproteinsIBA 01/2022 - 01/2018
3	Interleukin-10 (Interleukin 10)IBA 03/2021 - 11/2020
3	Amyloid Precursor Protein Secretases (beta-Secretase)IBA 01/2018 - 01/2004
3	polyglutamineIBA 01/2018 - 08/2002
3	Glutamine (L-Glutamine)FDA Link 04/2007 - 03/2002
2	Biomarkers (Surrogate Marker)IBA 01/2022 - 05/2011
2	ProteomeIBA 01/2020 - 12/2018
2	Biological ProductsIBA 01/2020 - 01/2012
2	DNA-Binding Proteins (DNA Binding Protein)IBA 01/2015 - 07/2013
2	MetalsIBA 01/2014 - 05/2012
2	AntibodiesIBA 08/2013 - 01/2008
2	DisulfidesIBA 01/2012 - 05/2008
2	Peptide Hydrolases (Proteases)FDA Link 01/2012 - 12/2005
2	Detergents (Detergent)IBA 05/2008 - 03/2008
2	Complementary DNA (cDNA)IBA 04/2008 - 12/2005
1	Doxycycline (Periostat)FDA LinkGeneric 01/2022
1	Pharmaceutical PreparationsIBA 01/2022
1	Protein Isoforms (Isoforms)IBA 01/2022
1	Apolipoprotein E3IBA 01/2022
1	Apolipoprotein E2IBA 01/2022
1	PresenilinsIBA 01/2021
1	Intermediate Filament ProteinsIBA 01/2021
1	CytokinesIBA 11/2020
1	Chemokine ReceptorsIBA 11/2020
1	Glucose (Dextrose)FDA LinkGeneric 01/2020
1	Myelin ProteinsIBA 01/2019
1	RNA-Binding Proteins (RNA-Binding Protein)IBA 01/2019
1	Nuclear Matrix-Associated ProteinsIBA 11/2016
1	Carrier Proteins (Binding Protein)IBA 10/2016
1	NucleotidesIBA 10/2016
1	4-O-carboxymethylascochlorinIBA 01/2016
1	Flavin-Adenine Dinucleotide (FAD)IBA 11/2015
1	Crystallins (Crystallin)IBA 05/2015
1	InterleukinsIBA 01/2015
1	RNA (Ribonucleic Acid)IBA 01/2015
1	Antineoplastic Agents (Antineoplastics)IBA 05/2013
1	Bexarotene (LGD1069)FDA Link 05/2013
1	LDL Receptors (LDL Receptor)IBA 01/2012
1	Metalloproteases (Metalloproteinases)IBA 01/2012
1	Caspase 6IBA 07/2011
1	alpha-Crystallin B ChainIBA 06/2010
1	alpha-SynucleinIBA 06/2010
1	CREB-Binding ProteinIBA 04/2010
1	Messenger RNA (mRNA)IBA 08/2008
1	Small Heat-Shock ProteinsIBA 04/2008
1	Prion ProteinsIBA 04/2008
1	LigandsIBA 01/2007

Therapy/Procedure

9	Therapeutics 03/2021 - 01/2012
2	Immunomodulation 02/2021 - 11/2020
1	Muscle Denervation 01/2016
1	Transplantation 01/2012